Published November 28, 2022

Laboratoires FILORGA’s story begins in 1978, when Dr. Michel Tordjman invented a unique injectable anti-aging solution capable of acting on the processes that influence skin aging. This was followed by close collaboration with aesthetic doctors from all over the world who adopted FILORGA products — particularly Dr. Tordjman’s poly-revitalizing solution.

But, regardless of their effectiveness, injections can be intimidating to some people. So, with the objective of making their scientific and aesthetic expertise as widely available as possible, FILORGA’s experts developed NCEF [New Cellular Encapsulated Factors], a unique complex directly inspired by the anti-aging solution invented by Dr. Tordjman over 45 years ago.

It is this signature Laboratoires FILORGA ingredient that we are going to look at today.


NCEF, FILORGA’s game changer, is a unique complex that forms the backbone of our anti-aging treatments

NCEF is the core complex of Laboratoires FILORGA's unique formula. It provides elements that are essential for the proper functioning of the cells while respecting the skin's natural mechanisms. 

In order to cross the skin barrier and distribute the active ingredients throughout the skin’s various layers, FILORGA employs state-of-the-art encapsulation technology resulting from scientific research: the ingredients are encapsulated in multilamellar liposomes — small spheres made up of around a hundred microscopic layers between which the active ingredients are inserted. The outer layers are made up of phospholipids, which are able to cross the skin barrier thanks to their molecules’ affinity with epidermal cells.

The liposomes act as small vehicles for the active ingredients which, upon arriving at their destination, are released into the deeper layers of the skin to begin their task of repairing, moisturizing, or nourishing.


NCEF includes active ingredients used in cosmetic injections

NCEF incorporates a complex of ingredients, the same as those used in injections:

- High molecular weight hyaluronic acid

- Amino acids

- Vitamins

- Minerals

- Coenzymes

If you would like to learn more about the active ingredients in NCEF and how they work to fill in wrinkles and revitalize the skin, our experts have written this article about the secrets of our signature complex.

Once its active ingredients are released, NCEF acts as a veritable booster, activating the skin's natural cellular mechanisms to fight signs of skin aging. To establish its effectiveness, FILORGA conducted ex vivo tests on human skin explants. The results demonstrated, among other things, that the activity of fibroblasts (the cells of the dermis that produce collagen, elastin, and hyaluronic acid) was stimulated.

This resulted in: 

- A significant 70% increase in the amount of collagen*

- A significant 22% increase in the amount of elastin*

NCEF is the key compound in all of Laboratoires FILORGA's skin care products.** 

SPOTLIGHT ON NCEF-SHOT — FILORGA's most concentrated NCEF product!

Filorga's NCEF-Shot 10 day anti-aging treatment

NCEF-SHOT is an innovative anti-aging product in the NCEF skin care collection. It is designed to be used as a 10-day treatment when your skin needs some extra help to deal with seasonal changes or to cope with stress and fatigue

Each application of NCEF-SHOT works on wrinkles and bolsters firmness and radiance, providing a complete and fast-acting anti-aging solution. It complements your daily beauty routine and should be applied morning and night before your serum and cream.

Easy-to-use and easy-to-dose thanks to its 0.75 ml graduated pipette, NCEF-SHOT received praise in all self-evaluation questionnaires: 9 out of 10 women noted a significant improvement in the quality of their skin*** after 10 days of twice-daily application of NCEF-SHOT. 

Explore the other products in the NCEF anti-aging product family, which is the FILORGA collection enriched with the most NCEF. 


*Ex vivo tests — Measurement of the amount of collagen and elastin after application of NCEF on skin explants for 5 days versus control.

**Except our sheet masks, micellar solution, and foam cleanser.

***Self-evaluation — 30 subjects after 10 days of twice-daily application of NCEF-SHOT Concentrate.